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Issue 25, 2010
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Catalytic enantioselective aldol additions of α-isothiocyanato imides to α-ketoesters

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Abstract

A readily available bifunctional thiourea catalyst promotes aldol additions of α-isothiocyanato imides to α-ketoesters under mild reaction conditions to form β-hydroxy-α-amino acid derivatives with high levels of enantioselectivity.

Graphical abstract: Catalytic enantioselective aldol additions of α-isothiocyanato imides to α-ketoesters

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Supplementary files

Article information


Submitted
24 Mar 2010
Accepted
27 Apr 2010
First published
19 May 2010

Chem. Commun., 2010,46, 4604-4606
Article type
Communication

Catalytic enantioselective aldol additions of α-isothiocyanato imides to α-ketoesters

M. K. Vecchione, L. Li and D. Seidel, Chem. Commun., 2010, 46, 4604
DOI: 10.1039/C0CC00556H

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