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Issue 23, 2010
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On-resin peptide macrocyclization using thiolene click chemistry

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Abstract

A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiolene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.

Graphical abstract: On-resin peptide macrocyclization using thiol–ene click chemistry

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Publication details

The article was received on 20 Jan 2010, accepted on 23 Mar 2010 and first published on 08 Apr 2010


Article type: Communication
DOI: 10.1039/C001375G
Chem. Commun., 2010,46, 4061-4063

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    On-resin peptide macrocyclization using thiolene click chemistry

    A. A. Aimetti, R. K. Shoemaker, C. Lin and K. S. Anseth, Chem. Commun., 2010, 46, 4061
    DOI: 10.1039/C001375G

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