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Issue 15, 2010
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Kinetic resolution of trans-cycloalkane-1,2-diols via Steglich esterification

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Abstract

We describe the efficient and highly enantioselective kinetic resolution of trans-cycloalkane-1,2-diols utilizing an enantioselective Steglich reaction with a variety of carboxylic acids that form the corresponding anhydrides in situ.

Graphical abstract: Kinetic resolution of trans-cycloalkane-1,2-diols via Steglich esterification

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Article information


Submitted
18 Jan 2010
Accepted
01 Feb 2010
First published
25 Feb 2010

Chem. Commun., 2010,46, 2689-2690
Article type
Communication

Kinetic resolution of trans-cycloalkane-1,2-diols via Steglich esterification

R. Hrdina, C. E. Müller and P. R. Schreiner, Chem. Commun., 2010, 46, 2689
DOI: 10.1039/C001075H

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