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Issue 24, 2010
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Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another

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Abstract

Mature fibrils prepared from apo-α-lactalbumin spontaneously refold from one polymorph to another as a result of a mild alteration in solution temperature and salinity. This discovery changes the very concept of the extraordinary stability of amyloid fibrils and presages a new approach for potentially regulating the biological activity of fibrils and their associated toxicity.

Graphical abstract: Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another

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Article information


Submitted
18 Dec 2009
Accepted
15 Jan 2010
First published
27 Jan 2010

Chem. Commun., 2010,46, 4249-4251
Article type
Communication

Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another

D. Kurouski, W. Lauro and I. K. Lednev, Chem. Commun., 2010, 46, 4249
DOI: 10.1039/B926758A

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