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Issue 12, 2010
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Site-specific pKa determination of the carboxylate-binding subunit in artificial peptide receptors

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Abstract

Site-specific pKa determination of the carboxylate-binding subunit in artificial peptide receptors is achieved by pH-dependent UV resonance Raman scattering with subsequent matrix factorization. This quantitative methodology allows to determine accurately the local acidity of a binding site based on the complete vibrational spectrum and, most importantly, without the need of selecting any particular peak.

Graphical abstract: Site-specific pKa determination of the carboxylate-binding subunit in artificial peptide receptors

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Article information


Submitted
15 Dec 2009
Accepted
01 Feb 2010
First published
17 Feb 2010

Chem. Commun., 2010,46, 2133-2135
Article type
Communication

Site-specific pKa determination of the carboxylate-binding subunit in artificial peptide receptors

S. Niebling, S. K. Srivastava, C. Herrmann, P. R. Wich, C. Schmuck and S. Schlücker, Chem. Commun., 2010, 46, 2133
DOI: 10.1039/B926514G

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