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Issue 16, 2010
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Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplexDNA aptamer

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Abstract

We demonstrate a strategy for label-free protein detection through monitoring the Surface Enhanced Raman Spectrum of an aptamer probe attached to a gold nanoshell. Low limit of detection and minimal non-specific binding show potential for in vitro and in vivo assays.

Graphical abstract: Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplex DNA aptamer

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Article information


Submitted
13 Oct 2009
Accepted
05 Feb 2010
First published
02 Mar 2010

Chem. Commun., 2010,46, 2799-2801
Article type
Communication

Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplex DNA aptamer

M. A. Ochsenkühn and C. J. Campbell, Chem. Commun., 2010, 46, 2799
DOI: 10.1039/B920941G

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