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Issue 4, 2010
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Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRASG-quadruplexes

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Abstract

Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.

Graphical abstract: Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

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Supplementary files

Article information


Submitted
14 Sep 2009
Accepted
23 Oct 2009
First published
20 Nov 2009

Chem. Commun., 2010,46, 625-627
Article type
Communication

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

A. Membrino, M. Paramasivam, S. Cogoi, J. Alzeer, N. W. Luedtke and L. E. Xodo, Chem. Commun., 2010, 46, 625
DOI: 10.1039/B918964E

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