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Issue 45, 2010
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A simple strategy for the construction of combinatorial cyclic peptoid libraries

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Abstract

Here we describe a simple method that allows for rapid and easy sequence determination of cyclic peptoids. The key idea in this strategy is a post-screening “ring-opening” reaction to convert cyclic peptoids selected from a high-throughput screen into linear peptoids, which can be sequenced by tandem mass spectrometry. Thus, there is no need for encoding.

Graphical abstract: A simple strategy for the construction of combinatorial cyclic peptoid libraries

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Article information


Submitted
15 Aug 2010
Accepted
13 Sep 2010
First published
04 Oct 2010

Chem. Commun., 2010,46, 8615-8617
Article type
Communication

A simple strategy for the construction of combinatorial cyclic peptoid libraries

J. H. Lee, A. M. Meyer and H. Lim, Chem. Commun., 2010, 46, 8615
DOI: 10.1039/C0CC03272G

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