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Issue 37, 2010
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Copper-induced cytotoxicity: reactive oxygen species or islet amyloidpolypeptide oligomer formation

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Abstract

Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes.

Graphical abstract: Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation

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Publication details

The article was received on 28 Jun 2010, accepted on 09 Aug 2010 and first published on 23 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC02141E
Chem. Commun., 2010,46, 6909-6911

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    Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation

    Y. Yu, P. Lei, J. Hu, W. Wu, Y. Zhao and Y. Li, Chem. Commun., 2010, 46, 6909
    DOI: 10.1039/C0CC02141E

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