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Issue 30, 2010
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Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

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Abstract

By significantly circumventing the typical problem of high background induced by excess hemin itself, an ultrasensitive DNA amplified detection method is developed based on nicking endonuclease (NEase) assisted strand scission cycle, which is further successfully applied in cancer cell detection.

Graphical abstract: Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

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Supplementary files

Article information


Submitted
26 Feb 2010
Accepted
01 Apr 2010
First published
29 Apr 2010

Chem. Commun., 2010,46, 5509-5511
Article type
Communication

Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

S. Bi, J. Zhang and S. Zhang, Chem. Commun., 2010, 46, 5509 DOI: 10.1039/C0CC00127A

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