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Issue 14, 2010
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A flow-based synthesis of Imatinib: the API of Gleevec

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Abstract

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

Graphical abstract: A flow-based synthesis of Imatinib: the API of Gleevec

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Supplementary files

Article information


Submitted
25 Jan 2010
Accepted
23 Feb 2010
First published
05 Mar 2010

Chem. Commun., 2010,46, 2450-2452
Article type
Communication

A flow-based synthesis of Imatinib: the API of Gleevec

M. D. Hopkin, I. R. Baxendale and S. V. Ley, Chem. Commun., 2010, 46, 2450
DOI: 10.1039/C001550D

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