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Issue 25, 2010
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Biodegradable therapeutic MOFs for the delivery of bioactive molecules

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Abstract

A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.

Graphical abstract: Biodegradable therapeutic MOFs for the delivery of bioactive molecules

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Article information


Submitted
19 Jan 2010
Accepted
28 Apr 2010
First published
13 May 2010

Chem. Commun., 2010,46, 4526-4528
Article type
Communication

Biodegradable therapeutic MOFs for the delivery of bioactive molecules

S. R. Miller, D. Heurtaux, T. Baati, P. Horcajada, J. Grenèche and C. Serre, Chem. Commun., 2010, 46, 4526
DOI: 10.1039/C001181A

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