Jump to main content
Jump to site search

Issue 1, 2010
Previous Article Next Article

Pd-catalyzed cascade carbopalladation-annulation reaction of 3-(2-iodobenzyl)-indoles into fused 6/5/7/6- and 6/5/5/6- heterocyclic systems

Author affiliations

Abstract

Polycyclic indole structures, possessing fused seven-membered rings were efficiently synthesized via the Pd-catalyzed intramolecular carbopalladation-annulation of 3-(2-iodobenzyl)-indoles and alkynes. A remarkable base effect on the chemoselectivity of this transformation has been found: switching from Et3N to CsOAc completely reverses the reaction path to intramolecular cyclization forming fused five-membered rings.

Graphical abstract: Pd-catalyzed cascade carbopalladation-annulation reaction of 3-(2-iodobenzyl)-indoles into fused 6/5/7/6- and 6/5/5/6- heterocyclic systems

Back to tab navigation

Publication details

The article was received on 25 Sep 2009, accepted on 27 Oct 2009 and first published on 17 Nov 2009


Article type: Communication
DOI: 10.1039/B919991H
Chem. Commun., 2010,46, 150-152

  •   Request permissions

    Pd-catalyzed cascade carbopalladation-annulation reaction of 3-(2-iodobenzyl)-indoles into fused 6/5/7/6- and 6/5/5/6- heterocyclic systems

    N. Chernyak, D. Tilly, Z. Li and V. Gevorgyan, Chem. Commun., 2010, 46, 150
    DOI: 10.1039/B919991H

Search articles by author

Spotlight

Advertisements