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Issue 10, 2010
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Measurement of biomarkerproteins for point-of-care early detection and monitoring of cancer

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This critical review evaluates progress toward viable point-of-care protein biomarker measurements for cancer detection and diagnostics. The ability to measure panels of specific, selective cancer biomarker proteins in physicians' surgeries and clinics has the potential to revolutionize cancer detection, monitoring, and therapy. The dream envisions reliable, cheap, automated, technically undemanding devices that can analyze a patient's serum or saliva in a clinical setting, allowing on-the-spot diagnosis. Existing commercial products for protein assays are reliable in laboratory settings, but have limitations for point-of-care applications. A number of ultrasensitive immunosensors and some arrays have been developed, many based on nanotechnology. Multilabel detection coupled with high capture molecule density in immunosensors and arrays seems to be capable of detecting a wide range of protein concentrations with sensitivity ranging into the sub pg mL−1 level. Multilabel arrays can be designed to detect both high and ultralow abundance proteins in the same sample. However, only a few of the newer ultrasensitive methods have been evaluated with real patient samples, which is key to establishing clinical sensitivity and selectivity.

Graphical abstract: Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer

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Publication details

The article was received on 05 Apr 2010, accepted on 28 May 2010 and first published on 08 Jul 2010

Article type: Critical Review
DOI: 10.1039/C0AN00204F
Analyst, 2010,135, 2496-2511

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    Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer

    J. F. Rusling, C. V. Kumar, J. S. Gutkind and V. Patel, Analyst, 2010, 135, 2496
    DOI: 10.1039/C0AN00204F

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