Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate

Abstract

The one-pot synthesis of multisubstituted pyrazole derivatives was achieved viacatalyst-free 1,3-dipolar cycloaddition of ethyl diazoacetate and nitroalkenes as the key step and elimination of the leaving group (NO₂ or Br) followed by intramolecular proton transfer with satisfactory yields.