Issue 17, 2009
From the journal:

Organic & Biomolecular Chemistry

High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations†

Dhevalapally B. Ramachary,*a   Vidadala V. Narayana,a   M. Shiva Prasada  and  Kinthada Ramakumara  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Hyderabad-500 046, India
E-mail: ramsc@uohyd.ernet.in
Fax: +91-40-23012460

Abstract

An efficient amine-/ruthenium-catalyzed three-step process for the synthesis of Nefopam analogues was achieved through combinations of cascade enamine amination/iso-aromatization/allylation and diene or enyne metathesis as key steps starting from functionalized Hagemann's esters. In this communication, we discovered the application of ruthenium-catalysis on olefins containing free amines without in situ formation of salts.

Graphical abstract: High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations

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Article information

DOI
https://doi.org/10.1039/B910397J
Article type
Communication
Submitted
27 May 2009
Accepted
23 Jun 2009
First published
03 Jul 2009

Org. Biomol. Chem., 2009,7, 3372-3378

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High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations

D. B. Ramachary, V. V. Narayana, M. S. Prasad and K. Ramakumar, Org. Biomol. Chem., 2009, 7, 3372 DOI: 10.1039/B910397J

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