Issue 18, 2009
From the journal:

Organic & Biomolecular Chemistry

The in vitrotransport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1†

David Foley,ab   Myrtani Pieri,c   Rachel Pettecrew,a   Richard Price,a   Stephen Miles,a   Ho Kam Lam,a   Patrick Bailey*b  and  David Meredithc  

* Corresponding authors

a School of Chemistry, University of Manchester, Manchester, U.K.

b Faculty of Natural Sciences, Keele University, Keele, Staffordshire, U.K.
E-mail: p.bailey@natsci.keele.ac.uk
Fax: +44 (0)1782 584593
Tel: +44 (0)1782 584583

c School of Life Sciences, Oxford Brookes University, Headington, Oxford, U.K.

Abstract

A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

Graphical abstract: The in vitrotransport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

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DOI
https://doi.org/10.1039/B909221H
Article type
Communication
Submitted
11 May 2009
Accepted
07 Jul 2009
First published
20 Jul 2009

Org. Biomol. Chem., 2009,7, 3652-3656

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The in vitrotransport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

D. Foley, M. Pieri, R. Pettecrew, R. Price, S. Miles, H. K. Lam, P. Bailey and D. Meredith, Org. Biomol. Chem., 2009, 7, 3652 DOI: 10.1039/B909221H

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