Issue 7, 2009

Synthesis of azepino[4,5-b]indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine

Abstract

A two-step protocol for the synthesis of azepino[4,5-b]indolone derivatives featuring a xanthate radical oxidative aromatic substitution on the N-Boc protected tryptamine, using dilauroyl peroxide (DLP) as initiator and oxidant, is described.

Graphical abstract: Synthesis of azepino[4,5-b]indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine

Supplementary files

Article information

Article type
Paper
Submitted
28 Nov 2008
Accepted
20 Jan 2009
First published
23 Feb 2009

Org. Biomol. Chem., 2009,7, 1388-1396

Synthesis of azepino[4,5-b]indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine

P. E. Reyes-Gutiérrez, R. O. Torres-Ochoa, R. Martínez and L. D. Miranda, Org. Biomol. Chem., 2009, 7, 1388 DOI: 10.1039/B821260K

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