A new domino reaction for the highly selective synthesis of tetracyclic cinnolino[5,4,3-cde]cinnolines using steric control was described. In this reaction, the use of anthenes with aliphatic groups (R1) leads to cinnolino[5,4,3-cde]cinnolines whereas anthenes with aryl groups (R1) result in N-amino-1,8-dioxoacridines.
![Graphical abstract: New domino reaction for the selective synthesis of tetracyclic cinnolino[5,4,3-cde]cinnolines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=B817930A&imageInfo.ImageIdentifier.Year=2009)
B. Jiang, W. Hao, J. Zhang, S. Tu and F. Shi, Org. Biomol. Chem., 2009, 7, 1171 DOI: 10.1039/B817930A
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