Issue 3, 2009
From the journal:

Organic & Biomolecular Chemistry

Tandem copper-catalysed aryl and alkenyl amination reactions: the synthesis of N-functionalised indoles†

Roy C. Hodgkinson,a   Jurgen Schulzb  and  Michael C. Willis*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK
E-mail: michael.willis@chem.ox.ac.uk
Fax: +44 1865 285002
Tel: +44 1865 285126

b Schering Plough Corporation, Newhouse, UK

Abstract

A Cu-diamine complex effectively catalyses tandem C–N bond formation on 2-(2-haloalkenyl)-aryl halide substrates, to deliver a series of N-functionalised indoles. Anilines, amides and carbamates are all effective coupling partners under the developed conditions.

Graphical abstract: Tandem copper-catalysed aryl and alkenyl amination reactions: the synthesis of N-functionalised indoles

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Article information

DOI
https://doi.org/10.1039/B817254D
Article type
Communication
Submitted
01 Oct 2008
Accepted
01 Dec 2008
First published
09 Dec 2008

Org. Biomol. Chem., 2009,7, 432-434

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Tandem copper-catalysed aryl and alkenyl amination reactions: the synthesis of N-functionalised indoles

R. C. Hodgkinson, J. Schulz and M. C. Willis, Org. Biomol. Chem., 2009, 7, 432 DOI: 10.1039/B817254D

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