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Issue 1, 2009
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A straightforward approach towards glycoamino acids and glycopeptidesviaPd-catalysed allylic alkylation

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Abstract

Chelated enolates are versatile nucleophiles for palladium-catalysed allylic alkylations. Even with complex allylic substrates the reaction proceed without significant isomerisation. This allows the stereoselective introduction of polyhydroxylated allylic sidechains into amino acids and peptides with retention of the olefin geometry.

Graphical abstract: A straightforward approach towards glycoamino acids and glycopeptidesviaPd-catalysed allylic alkylation

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Article information


Submitted
12 Aug 2008
Accepted
24 Sep 2008
First published
31 Oct 2008

Org. Biomol. Chem., 2009,7, 103-110
Article type
Paper

A straightforward approach towards glycoamino acids and glycopeptidesviaPd-catalysed allylic alkylation

K. Krämer, J. Deska, C. Hebach and U. Kazmaier, Org. Biomol. Chem., 2009, 7, 103
DOI: 10.1039/B813978D

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