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Issue 1, 2009
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A straightforward approach towards glycoamino acids and glycopeptidesviaPd-catalysed allylic alkylation

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Abstract

Chelated enolates are versatile nucleophiles for palladium-catalysed allylic alkylations. Even with complex allylic substrates the reaction proceed without significant isomerisation. This allows the stereoselective introduction of polyhydroxylated allylic sidechains into amino acids and peptides with retention of the olefin geometry.

Graphical abstract: A straightforward approach towards glycoamino acids and glycopeptidesviaPd-catalysed allylic alkylation

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Publication details

The article was received on 12 Aug 2008, accepted on 24 Sep 2008 and first published on 31 Oct 2008


Article type: Paper
DOI: 10.1039/B813978D
Org. Biomol. Chem., 2009,7, 103-110

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    A straightforward approach towards glycoamino acids and glycopeptidesviaPd-catalysed allylic alkylation

    K. Krämer, J. Deska, C. Hebach and U. Kazmaier, Org. Biomol. Chem., 2009, 7, 103
    DOI: 10.1039/B813978D

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