Issue 1, 2009
From the journal:

Organic & Biomolecular Chemistry

Cleavage of RNA oligonucleotides by aminoglycosides†‡

Matthew J. Belousoff,ab   Bim Graham,c   Leone Spiccia*a  and  Yitzhak Tor*b  

* Corresponding authors

a School of Chemistry, Monash University, Clayton, Australia
E-mail: leone.spiccia@sci.monash.edu.au
Fax: +61 3 9905 4597
Tel: +61 9905 4526

b Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA
E-mail: ytor@ucsd.edu
Fax: +1 858 534 0202
Tel: +1 858 534 6401

c Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
E-mail: bim.graham@pharm.monash.edu.au
Fax: +61 3 9903 9582
Tel: +61 3 9903 9706

Abstract

A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.

Graphical abstract: Cleavage of RNA oligonucleotides by aminoglycosides

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Article information

DOI
https://doi.org/10.1039/B813252F
Article type
Communication
Submitted
31 Jul 2008
Accepted
22 Oct 2008
First published
30 Oct 2008

Org. Biomol. Chem., 2009,7, 30-33

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Cleavage of RNA oligonucleotides by aminoglycosides

M. J. Belousoff, B. Graham, L. Spiccia and Y. Tor, Org. Biomol. Chem., 2009, 7, 30 DOI: 10.1039/B813252F

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