Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
Abstract
Covering: up to 2008
Ecteinascidins are marine natural products consisting of two or three linked tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their potent antiproliferative activity against a variety of tumor cells makes them attractive candidates for development as anticancer agents. The lead compound,