Issue 8, 2009

New natural product biosynthetic chemistry discovered by genome mining

Abstract

Covering: 2000 to 2008

Analyses of plant and microbial genome sequences have revealed many genes and gene clusters encoding proteins similar to those known to be involved in the biosynthesis of structurally-complex natural products. Many of these genes and gene clusters do not direct the production of known metabolites of the organism in which they are found. Others represent novel gene clusters that direct the biosynthesis of known natural products. This article highlights several examples of new biosynthetic chemistry discovered in the course of investigating such gene clusters.

Graphical abstract: New natural product biosynthetic chemistry discovered by genome mining

Article information

Article type
Highlight
Submitted
13 Mar 2009
First published
22 May 2009

Nat. Prod. Rep., 2009,26, 977-986

New natural product biosynthetic chemistry discovered by genome mining

C. Corre and G. L. Challis, Nat. Prod. Rep., 2009, 26, 977 DOI: 10.1039/B713024B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements