Issue 5, 2009

Transport of chloride ion through phospholipid bilayers mediated by synthetic ionophores

Abstract

Chloride has emerged as one of the most vigorously studied ions that occur in nature. A continuing motivation for the study of chloride transport lies in the pathological conditions that relate to or involve chloride transport. The goal of the organic, biological, or supramolecular chemist, thus, is to understand binding strength, binding dynamics, binding selectivity, transport selectivity and dynamics of chloride transporters. Various successful anion transporters or channels are now known, although detailed characterization and elaboration in most cases is ongoing. Several of these synthetic systems will be discussed in this review as we focus our discussion on the efforts to develop artificial transporters for chloride anions.

Graphical abstract: Transport of chloride ion through phospholipid bilayers mediated by synthetic ionophores

Article information

Article type
Perspective
Submitted
01 Oct 2008
Accepted
10 Dec 2008
First published
30 Jan 2009

New J. Chem., 2009,33, 947-963

Transport of chloride ion through phospholipid bilayers mediated by synthetic ionophores

G. W. Gokel and N. Barkey, New J. Chem., 2009, 33, 947 DOI: 10.1039/B817245P

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