Intramolecular hydrogen bonding as a determinant of the inhibitory potency of N-unsubstituted imidazole derivatives towards mammalian hemoproteins†
Abstract
Enzymes involved in the mammalian microsomal
* Corresponding authors
a
URA 2096 du CNRS, Institut de Biologie et Technologies de Saclay, Commissariat à l’Energie Atomique, Bâtiment 528, CEA-Saclay, Gif-sur-Yvette, France
E-mail:
marcel.delaforge@cea.fr
Fax: +33 1 69 08 87 17
Tel: +33 1 69 08 68 39
b INSERM U620; Université de Rennes 1, IFR 140, 2 Avenue du Pr. Léon Bernard, Rennes, France
c
Laboratoire de Chimie Bioorganique et Bioinorganique, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, Bâtiment 420, Université Paris-Sud XI, Orsay, France
E-mail:
jpmahy@icmo.u-psud.fr
Fax: +33 1 69 15 72 81
Tel: +33 1 69 15 74 21
d Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, USA
Enzymes involved in the mammalian microsomal
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