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Issue 12, 2009
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Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

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Abstract

Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblastgrowth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.

Graphical abstract: Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

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Article information


Submitted
31 Mar 2009
Accepted
03 Jul 2009
First published
06 Aug 2009

Mol. BioSyst., 2009,5, 1456-1472
Article type
Review Article

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

S. Lee, A. Brown, W. R. Pitt, A. P. Higueruelo, S. Gong, G. R. Bickerton, A. Schreyer, D. Tanramluk, A. Baylay and T. L. Blundell, Mol. BioSyst., 2009, 5, 1456
DOI: 10.1039/B906402H

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