Decoding biological principles using gene circuits

Abstract

A major flavor of synthetic biology is the creation of artificial gene circuits to perform user-defined tasks. One aspect of this area is to realize ever-increasingly more complicated circuit behavior. Such efforts have led to the identification and evaluation of design strategies that enable robust control of dynamics in single cells and in cell populations. On the other hand, there is increasing emphasis on using artificial systems programmed by simple circuits to explore fundamental biological questions of broad significance.