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Issue 14, 2009
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Self-powered microfluidic chips for multiplexed protein assays from whole blood

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Abstract

We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.

Graphical abstract: Self-powered microfluidic chips for multiplexed protein assays from whole blood

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Article information


Submitted
27 Nov 2008
Accepted
25 Mar 2009
First published
16 Apr 2009

Lab Chip, 2009,9, 2016-2020
Article type
Paper

Self-powered microfluidic chips for multiplexed protein assays from whole blood

L. Qin, O. Vermesh, Q. Shi and J. R. Heath, Lab Chip, 2009, 9, 2016
DOI: 10.1039/B821247C

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