Issue 6, 2009

Flow-free transport of cells in microchannels by frequency-modulated ultrasound

Abstract

We demonstrate flow-free transport of cells and particles by the use of frequency-modulated ultrasonic actuation of a microfluidic chip. Two different modulation schemes are combined: A rapid (1 kHz) linear frequency sweep around ∼6.9 MHz is used for two-dimensional spatial stabilization of the force field over a 5 mm long inlet channel of constant cross section, and a slow (0.2–0.7 Hz) linear frequency sweep around ∼2.6 MHz is used for flow-free ultrasonic transport and positioning of cells or particles. The method is used for controlling the motion and position of cells monitored with high-resolution optical microscopy, but can also be used more generally for improving the robustness and performance of ultrasonic manipulation micro-devices.

Graphical abstract: Flow-free transport of cells in microchannels by frequency-modulated ultrasound

Supplementary files

Article information

Article type
Technical Note
Submitted
13 Oct 2008
Accepted
09 Jan 2009
First published
02 Feb 2009

Lab Chip, 2009,9, 833-837

Flow-free transport of cells in microchannels by frequency-modulated ultrasound

O. Manneberg, B. Vanherberghen, B. Önfelt and M. Wiklund, Lab Chip, 2009, 9, 833 DOI: 10.1039/B816675G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements