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Issue 31, 2009
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Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

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Abstract

Nanoscale carriers are of increasing interest for use in anticancer therapy because they can deliver drugs in a targeted way. Ideally, nanocarriers combine passive and active delivery mechanisms, by integrating targeting ligands on the surface of their stealth corona using simple and efficient conjugation chemistry. This feature article summarizes the conventional and newly explored conjugation chemistries that are used to bind ligands in organic nanoparticle systems, providing strategic guidance for the preparation of targeted nanocarriers.

Graphical abstract: Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

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Publication details

The article was received on 11 Dec 2008, accepted on 09 Mar 2009 and first published on 09 Apr 2009


Article type: Feature Article
DOI: 10.1039/B822319J
Citation: J. Mater. Chem., 2009,19, 5485-5498

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    Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

    M. Shi, J. Lu and M. S. Shoichet, J. Mater. Chem., 2009, 19, 5485
    DOI: 10.1039/B822319J

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