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Issue 31, 2009
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Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

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Abstract

Nanoscale carriers are of increasing interest for use in anticancer therapy because they can deliver drugs in a targeted way. Ideally, nanocarriers combine passive and active delivery mechanisms, by integrating targeting ligands on the surface of their stealth corona using simple and efficient conjugation chemistry. This feature article summarizes the conventional and newly explored conjugation chemistries that are used to bind ligands in organic nanoparticle systems, providing strategic guidance for the preparation of targeted nanocarriers.

Graphical abstract: Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

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Article information


Submitted
11 Dec 2008
Accepted
09 Mar 2009
First published
09 Apr 2009

J. Mater. Chem., 2009,19, 5485-5498
Article type
Feature Article

Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

M. Shi, J. Lu and M. S. Shoichet, J. Mater. Chem., 2009, 19, 5485
DOI: 10.1039/B822319J

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