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Issue 6, 2009
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Bioactive functional materials: a perspective on phosphate-based glasses

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The general trend in biomaterials is to use and employ materials that play an active role in tissue regeneration rather than passive and inert materials. Therefore, understanding how a material interacts with the surrounding environments, including cells and tissue fluid, allows material design to be tailored so that implants can be constructed to promote a specific biological response, helping them better perform their function. This class of materials has been described as the “Third Generation” of biomaterials. Phosphate based glasses fall into this category and it has been shown that the properties of these glasses can be tuned via their composition according to the desired end application. These glasses can be prepared as melt-quenched or sol-gel bulk form suitable for potential hard tissue engineering applications and as vehicles for antimicrobial agents. They can also be prepared as fibres suitable for soft tissue engineering applications such as those involving muscle, ligaments, and tendon, where, like the fibres, the tissue has a high degree of anisotropy.

Graphical abstract: Bioactive functional materials: a perspective on phosphate-based glasses

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Publication details

The article was received on 24 Jun 2008, accepted on 17 Sep 2008 and first published on 04 Nov 2008

Article type: Feature Article
DOI: 10.1039/B810675D
J. Mater. Chem., 2009,19, 690-701

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    Bioactive functional materials: a perspective on phosphate-based glasses

    E. A. Abou Neel, D. M. Pickup, S. P. Valappil, R. J. Newport and J. C. Knowles, J. Mater. Chem., 2009, 19, 690
    DOI: 10.1039/B810675D

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