Issue 6, 2009

Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

Abstract

Novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides were prepared in one step by nucleophilic substitution reaction of 6-choloropurine nucleosides with diethanolamine. Shorter reaction times and higher yields were achieved under microwave irradiation conditions in neat water.

Graphical abstract: Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

Supplementary files

Article information

Article type
Communication
Submitted
02 Feb 2009
Accepted
06 Mar 2009
First published
16 Mar 2009

Green Chem., 2009,11, 760-762

Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

G. Qu, J. Wu, Y. Wu, F. Zhang and H. Guo, Green Chem., 2009, 11, 760 DOI: 10.1039/B902025J

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