Issue 2, 2009
From the journal:

Green Chemistry

Synthesis of pyrazoles through catalyst-free cycloaddition of diazo compounds to alkynes†

Daniela Vuluga,a   Julien Legros,*a   Benoît Croussea  and  Danièle Bonnet-Delpona  

* Corresponding authors

a Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ Paris Sud, rue JB Clément, Châtenay-Malabry, France
E-mail: julien.legros@u-psud.fr
Fax: +33 1 46 83 57 40
Tel: +33 1 46 83 57 38

Abstract

The synthesis of pyrazoles via1,3-dipolar cycloaddition of diazo compounds to alkynes proceeds easily by heating. With α-diazocarbonyl substrates the reactions are conducted under solvent-free conditions affording the pyrazole products in high yields without any work up or purification.

Graphical abstract: Synthesis of pyrazoles through catalyst-free cycloaddition of diazo compounds to alkynes

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Article information

DOI
https://doi.org/10.1039/B812242C
Article type
Communication
Submitted
24 Jul 2008
Accepted
25 Nov 2008
First published
09 Dec 2008

Green Chem., 2009,11, 156-159

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Synthesis of pyrazoles through catalyst-free cycloaddition of diazo compounds to alkynes

D. Vuluga, J. Legros, B. Crousse and D. Bonnet-Delpon, Green Chem., 2009, 11, 156 DOI: 10.1039/B812242C

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