A new bifunctional GdIII complex of enhanced efficacy for MR-molecular imaging applications

Lorenzo Tei; Giuseppe Gugliotta; Zsolt Baranyai; Mauro Botta

doi:10.1039/B917566K

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A new bifunctional Gd^III complex of enhanced efficacy for MR-molecular imaging applications†

Lorenzo Tei,^a Giuseppe Gugliotta,^a Zsolt Baranyai^b and Mauro Botta*^a

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* Corresponding authors

^a Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale “Amedeo Avogadro”, Viale T. Michel 11, Alessandria, Italy
E-mail: mauro.botta@mfn.unipmn.it

^b Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, Debrecen, Hungary

Abstract

Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (k_ex) by nearly two orders of magnitude; the ¹H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.

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Article information

DOI: https://doi.org/10.1039/B917566K
Article type: Communication
Submitted: 19 Jun 2009
Accepted: 04 Sep 2009
First published: 15 Sep 2009

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Dalton Trans., 2009, 9712-9714

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A new bifunctional Gd^III complex of enhanced efficacy for MR-molecular imaging applications

L. Tei, G. Gugliotta, Z. Baranyai and M. Botta, Dalton Trans., 2009, 9712 DOI: 10.1039/B917566K

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Dalton Transactions