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Issue 48, 2009
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Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors

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Abstract

The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a γ-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing methods for NO delivery to specific physiological targets. In this Perspective, we describe ongoing investigations focused on photochemical methodologies to deliver therapeutic doses of NO to such targets utilizing transition metal complexes that are nitric oxide precursors. The photochemical strategy has the advantages that it allows for precise control of the timing, location, and dosage for the targeted delivery of a bioactive agent.

Graphical abstract: Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors

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Article information


Submitted
30 Jun 2009
Accepted
14 Aug 2009
First published
27 Aug 2009

Dalton Trans., 2009, 10660-10669
Article type
Perspective

Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors

A. D. Ostrowski and P. C. Ford, Dalton Trans., 2009, 10660
DOI: 10.1039/B912898K

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