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Issue 35, 2009
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Metal-NHC complexes: a survey of anti-cancer properties

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Abstract

New weapons to fight cancer are constantly needed. Among chemotherapeutics, anti-cancer metal-drugs have enjoyed a long and successful history since the discovery of the benchmark cisplatin. Advances in metal-drug discovery have motivated chemists to build plethora of complex structures. Among them, a novel area is emerging. This article presents a survey of the metal-N-Heterocyclic Carbenes (Ag(I), Au(I), Pd(II) and Cu(I)-NHCs) as potential anti-cancer agents. Most of the metal-NHCs considered display higher cytotoxicities than the reference metallo-drug cisplatin. Some of them are even selective for particular cell lines. Their mechanisms of action at the cellular level are further discussed, showing that the nature of the metal is of great importance. All these promising results demonstrate that this approach deserves more attention and work.

Graphical abstract: Metal-NHC complexes: a survey of anti-cancer properties

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Article information


Submitted
30 Mar 2009
Accepted
10 Jun 2009
First published
10 Jul 2009

Dalton Trans., 2009, 6894-6902
Article type
Perspective

Metal-NHC complexes: a survey of anti-cancer properties

M. Teyssot, A. Jarrousse, M. Manin, A. Chevry, S. Roche, F. Norre, C. Beaudoin, L. Morel, D. Boyer, R. Mahiou and A. Gautier, Dalton Trans., 2009, 6894
DOI: 10.1039/B906308K

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