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Issue 11, 2009
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The economies of synthesis

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In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.

Graphical abstract: The economies of synthesis

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The article was received on 05 May 2009 and first published on 21 Aug 2009

Article type: Tutorial Review
DOI: 10.1039/B821200G
Chem. Soc. Rev., 2009,38, 3010-3021

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    The economies of synthesis

    T. Newhouse, P. S. Baran and R. W. Hoffmann, Chem. Soc. Rev., 2009, 38, 3010
    DOI: 10.1039/B821200G

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