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Issue 4, 2009
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Recent advances in enantioselective copper-catalyzed 1,4-addition

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Abstract

A comprehensive overview of recent literature from 2003 concerning advances in enantioselective copper catalysed 1,4-addition of organometallic reagents to α,β-unsaturated compounds is given in this critical review. About 200 ligands and catalysts are presented, with a focus on stereoselectivities, catalyst loading, ligand structure and substrate scope. A major part is devoted to trapping and tandem reactions and a variety of recent synthetic applications are used to illustrate the practicality and current state of the art of 1,4-addition of organometallic reagents. Finally several mechanistic studies are discussed (162 references).

Graphical abstract: Recent advances in enantioselective copper-catalyzed 1,4-addition

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Article information


Submitted
25 Sep 2008
First published
11 Feb 2009

Chem. Soc. Rev., 2009,38, 1039-1075
Article type
Critical Review

Recent advances in enantioselective copper-catalyzed 1,4-addition

T. Jerphagnon, M. G. Pizzuti, A. J. Minnaard and B. L. Feringa, Chem. Soc. Rev., 2009, 38, 1039
DOI: 10.1039/B816853A

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