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Issue 2, 2009
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Understanding enzyme immobilisation

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Abstract

Enzymes are versatile catalysts in the laboratory and on an industrial scale. To broaden their applicability in the laboratory and to ensure their (re)use in manufacturing the stability of enzymes can often require improvement. Immobilisation can address the issue of enzymatic instability. Immobilisation can also help to enable the employment of enzymes in different solvents, at extremes of pH and temperature and exceptionally high substrate concentrations. At the same time substrate-specificity, enantioselectivity and reactivity can be modified. However, most often the molecular and physical–chemical bases of these phenomena have not been elucidated yet. This tutorial review focuses on the understanding of enzyme immobilisation.

Graphical abstract: Understanding enzyme immobilisation

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Article information


Submitted
27 Aug 2008
First published
09 Dec 2008

Chem. Soc. Rev., 2009,38, 453-468
Article type
Tutorial Review

Understanding enzyme immobilisation

U. Hanefeld, L. Gardossi and E. Magner, Chem. Soc. Rev., 2009, 38, 453
DOI: 10.1039/B711564B

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