Issue 5, 2009

Application of on-line Raman spectroscopy on monitoring semi-batch anti-solvent crystallization

Abstract

Anti-solvent crystallization of potassium dihydrogen phosphate (KDP) from aqueous solution was studied by using on-line Raman spectroscopy. The used anti-solvent was acetone and semi-batch crystallization experiments were conducted by adding acetone into an initially pure aqueous KDP solution saturated at 25 °C. The solubility of KDP in acetonewater mixtures was determined at 25 °C. A calibration model of Raman spectra was created using a series of KDP–wateracetone ternary or binary solutions, and the calibration model was used to attain the on-line KDP concentration profile during the crystallization. The evolution of supersaturation during the whole process was then obtained. The reliability of the calibration model was validated by the off-line measured KDP concentrations. The effects of the feeding rate and feeding position of the anti-solvent on precipitation were discussed based on the obtained supersaturation profile.

Graphical abstract: Application of on-line Raman spectroscopy on monitoring semi-batch anti-solvent crystallization

Article information

Article type
Paper
Submitted
02 Oct 2008
Accepted
16 Dec 2008
First published
27 Jan 2009

CrystEngComm, 2009,11, 827-831

Application of on-line Raman spectroscopy on monitoring semi-batch anti-solvent crystallization

B. Han, Z. Sha, H. Qu, M. Louhi-Kultanen and X. Wang, CrystEngComm, 2009, 11, 827 DOI: 10.1039/B817299D

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