An L-proline based supramolecular hydrogel is used as an efficient heterogeneous organocatalyst for the direct aldol reaction with high stereoselectivity (up to 90% ee) and recyclability (up to 3 runs). The reversible nature of this self-assembled supramolecular system allows for easy recovery and regeneration of the catalyst.
F. Rodríguez-Llansola, J. F. Miravet and B. Escuder, Chem. Commun., 2009, 7303 DOI: 10.1039/B916250J
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