Issue 37, 2009
From the journal:

Chemical Communications

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles†

Vincent J. Venditto,a   Kimberly Allred,b   Clinton D. Allred*b  and  Eric E. Simanek*a  

* Corresponding authors

a Department of Chemistry, Texas A&M University, College Station, USA
E-mail: simanek@tamu.edu
Fax: +1-979-845-9452
Tel: +1-979-845-4242

b Department of Nutrition and Food Science, Texas A&M University, College Station, USA
E-mail: callred@ag.tamu.edu
Fax: +1-979-862-7782
Tel: +1-979-845-0863

Abstract

The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

Graphical abstract: Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles

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Article information

DOI
https://doi.org/10.1039/B911353C
Article type
Communication
Submitted
10 Jun 2009
Accepted
20 Jul 2009
First published
11 Aug 2009

Chem. Commun., 2009, 5541-5542

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Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles

V. J. Venditto, K. Allred, C. D. Allred and E. E. Simanek, Chem. Commun., 2009, 5541 DOI: 10.1039/B911353C

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