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Issue 36, 2009
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Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

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Abstract

Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.

Graphical abstract: Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

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Article information


Submitted
01 Jun 2009
Accepted
20 Jul 2009
First published
17 Aug 2009

Chem. Commun., 2009, 5377-5379
Article type
Communication

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

B. Vaz, S. Möcklinghoff, S. Folkertsma, S. Lusher, J. de Vlieg and L. Brunsveld, Chem. Commun., 2009, 5377
DOI: 10.1039/B910677D

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