Issue 44, 2009
From the journal:

Chemical Communications

Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinonechrysophanol†‡

Gerhard Bringmann,*a   Tobias A. M. Gulder,a   Andreas Hamm,a   Michael Goodfellowb  and  Hans-Peter Fiedler*c  

* Corresponding authors

a Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany
E-mail: bringman@chemie.uni-wuerzburg.de
Fax: +49 931 888 4755
Tel: +49 931 318 5323

b School of Biology, University of Newcastle, Newcastle upon Tyne, United Kingdom

c Institute of Microbiology, University of Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany
E-mail: hans-peter.fiedler@uni-tuebingen.de
Fax: +49 7071 29 5999
Tel: +49 7071 29 72079

Abstract

The polyketidechrysophanol is shown to be formed, in an organism-specific way, by a third folding mode, involving a remarkable cyclization of a bicyclic diketo precursor, thus establishing the first example of multiple convergence in polyketide biosynthesis.

Graphical abstract: Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinonechrysophanol

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Article information

DOI
https://doi.org/10.1039/B910501H
Article type
Communication
Submitted
28 May 2009
Accepted
17 Sep 2009
First published
05 Oct 2009

Chem. Commun., 2009, 6810-6812

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Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinonechrysophanol

G. Bringmann, T. A. M. Gulder, A. Hamm, M. Goodfellow and H. Fiedler, Chem. Commun., 2009, 6810 DOI: 10.1039/B910501H

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