G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer†
Abstract
Macrocyclic hexaoxazole (6OTD) dimers were designed as candidates for potent G-quadruplex binders and synthesized.
* Corresponding authors
a
Department of Biotechnology and Life Science Faculty of Technology, Tokyo University of Agriculture and Technology (TUAT), Koganei, Tokyo 184-8588, Japan
E-mail:
knaga@cc.tuat.ac.jp
Fax: +81-42-388-7295
Tel: +81-42-388-7295
b Computational Biology Research Center National Institute of Advanced Industrial Science and Technology, Koto-ku, Tokyo 135-0064, Japan
c Biological Information Research Center National Institute of Advanced Industrial Science and Technology, Koto-ku, Tokyo 135-0064, Japan
Macrocyclic hexaoxazole (6OTD) dimers were designed as candidates for potent G-quadruplex binders and synthesized.
K. Iida, M. Tera, T. Hirokawa, K. Shin-ya and K. Nagasawa, Chem. Commun., 2009, 6481 DOI: 10.1039/B910242F
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