Issue 22, 2009
From the journal:

Chemical Communications

Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids†

Dipanjan Pan,‡*a   Angana Senpan,‡a   Shelton D. Caruthers,ab   Todd A. Williams,a   Mike J. Scott,a   Patrick J. Gaffney,c   Samuel A. Wicklinea  and  Gregory M. Lanzaa  

* Corresponding authors

a Division of Cardiology and C-TRAIN, Washington University School of Medicine, St. Louis, USA
E-mail: dipanjan@wustl.edu
Fax: +1 314-454-7490
Tel: +1 314-454-7674

b Philips HealthCare, Andover, Massachusetts, USA

c Department of Surgery, St. Thomas’s Hospital, London, UK

Abstract

In this work, we report novel fibrin targeted “soft-type” manganese-based contrast agents for MRI with the potential to noninvasively image intravascular thrombus which could warrant aggressive medical intervention to preclude subsequent myocardial infarction or stroke.

Graphical abstract: Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids

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Article information

DOI
https://doi.org/10.1039/B902875G
Article type
Communication
Submitted
11 Feb 2009
Accepted
06 Apr 2009
First published
22 Apr 2009

Chem. Commun., 2009, 3234-3236

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Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids

D. Pan, A. Senpan, S. D. Caruthers, T. A. Williams, M. J. Scott, P. J. Gaffney, S. A. Wickline and G. M. Lanza, Chem. Commun., 2009, 3234 DOI: 10.1039/B902875G

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