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Issue 16, 2009
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Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

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Abstract

An efficient and convenient Negishi coupling protocol was developed for the preparation of 3-aryl-2,2-dimethylpropanoates providing easy access to key pharmaceutical intermediates that often require multi-step synthesis using conventional enolate chemistry.

Graphical abstract: Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

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Publication details

The article was received on 10 Feb 2009, accepted on 05 Mar 2009 and first published on 23 Mar 2009


Article type: Communication
DOI: 10.1039/B902779C
Chem. Commun., 2009, 2145-2147

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    Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

    Y. Kwak, A. D. Kanter, B. Wang and Y. Liu, Chem. Commun., 2009, 2145
    DOI: 10.1039/B902779C

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