Issue 20, 2009
From the journal:

Chemical Communications

Effect of microwave irradiation on covalent ligand–DNA interactions†

Khondaker M. Rahmana  and  David E. Thurston*a  

* Corresponding authors

a Gene Targeted Drug Design Research Group, School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK
E-mail: david.thurston@pharmacy.ac.uk
Fax: +44 (0)20 7753 5964
Tel: +44 (0)20 7753 5931

Abstract

A 30 second burst of microwave irradiation at an energy level insufficient to cause DNA denaturation or damage drives the covalent reaction between pyrrolobenzodiazepine (PBD) antitumour agents and double-stranded or hairpin oligonucleotides to completion, a process that normally takes between 3–24 hours and thus offering the opportunity for higher-throughput screening of covalent-binding DNA-interactive agents.

Graphical abstract: Effect of microwave irradiation on covalent ligand–DNA interactions

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Article information

DOI
https://doi.org/10.1039/B902357G
Article type
Communication
Submitted
04 Feb 2009
Accepted
09 Mar 2009
First published
03 Apr 2009

Chem. Commun., 2009, 2875-2877

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Effect of microwave irradiation on covalent ligand–DNA interactions

K. M. Rahman and D. E. Thurston, Chem. Commun., 2009, 2875 DOI: 10.1039/B902357G

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