Issue 19, 2009
From the journal:

Chemical Communications

Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments†

Eryun Yan,ab   Yin Ding,b   Changjing Chen,b   Rutian Li,c   Yong Hu*a  and  Xiqun Jiang*b  

* Corresponding authors

a National Laboratory of Solid State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing, P.R. China

b Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, P.R. China

c Department of Oncology, Drum Tower Hospital Affiliated to Nanjing University, Nanjing, PR China
E-mail: hvyong@nju.edu.cn, jiangx@nju.edu.cn

Abstract

Hybrid hollow nanospheres of chitosan–silica templated by chitosan–poly(acrylic acid) nanoparticles are fabricated in a complete aqueous system, which provide a pH-sensitive switch in physiological and sub-cell environments for the release of loaded drug.

Graphical abstract: Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments

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Article information

DOI
https://doi.org/10.1039/B900751B
Article type
Communication
Submitted
14 Jan 2009
Accepted
11 Mar 2009
First published
27 Mar 2009

Chem. Commun., 2009, 2718-2720

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Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments

E. Yan, Y. Ding, C. Chen, R. Li, Y. Hu and X. Jiang, Chem. Commun., 2009, 2718 DOI: 10.1039/B900751B

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